Analysis of human sperm DNA fragmentation index (DFI) related factors: a report of 1010 subfertile men in China.

ABSTRACT:

Background

Many factors may lead to sperm DNA damage. However, it is little known that the correlations of sperm DNA damage with obesity-associated markers, and reproductive hormones and lipids levels in serum and seminal plasma.

Methods

In our prospective study, a total of 1 010 subfertile men, aged from 18 to 50 years old, were enrolled from August 2012 through June 2015. Their obesity-associated markers, semen parameters, sperm acrosomal enzyme activity, seminal plasma biochemical markers, and reproductive hormones and lipids levels in serum and seminal plasma were detected. Sperm DNA fragmentation index (DFI) was determined by sperm chromatin structure assay. The correlations between DFI and each of the above-mentioned variables were analyzed.

Results

Spearman cor

SUBMITTER: Lu JC 

PROVIDER: S-EPMC5852972 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature