Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells.

ABSTRACT:

Background

Fibrinogen is a central player in the blood coagulation cascade and one of the most abundant plasma proteins. This glycoprotein also triggers important events (e.g., cell spreading, the respiratory burst and degranulation) in neutrophil cells via a α_Mβ₂ integrin-mediated binding to the cell surface. Yet, little is known about the interaction of fibrinogen with leukocytes other than neutrophils or stimulated monocytes, although high amounts of fibrinogen protein can also be found in lymphocytes, particularly in T-cells. The aim of the present work is to unveil the dynamics and the function of fibrinogen intake in T-cells.

Methods

Using the Jurkat cell line as a T-cells model we performed fibrinogen intake/competition experiments. Moreover, by

SUBMITTER: Alberio T 

PROVIDER: S-EPMC5853075 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature