Comprehensive subcellular topologies of polypeptides in Streptomyces.

ABSTRACT:

Background

Members of the genus Streptomyces are Gram-positive bacteria that are used as important cell factories to produce secondary metabolites and secrete heterologous proteins. They possess some of the largest bacterial genomes and thus proteomes. Understanding their complex proteomes and metabolic regulation will improve any genetic engineering approach.

Results

Here, we performed a comprehensive annotation of the subcellular localization of the proteome of Streptomyces lividans TK24 and developed the Subcellular Topology of Polypeptides in Streptomyces database (SToPSdb) to make this information widely accessible. We first introduced a uniform, improved nomenclature that re-annotated the names of ~ 4000 proteins based on functional and structural information. Then pro

SUBMITTER: Tsolis KC 

PROVIDER: S-EPMC5853079 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature