Loss of fragile histidine triad (Fhit) protein expression alters the translation of cancer-associated mRNAs.

ABSTRACT:

Objectives

In > 50% of cancers tumor development involves the early loss of Fhit (fragile histidine triad) protein expression, yet the mechanistic pathway(s) by which Fhit mediates its tumor suppressor functions are not fully understood. Earlier attempts to identify a Fhit-deficient gene expression profile relied on total cellular RNA and microarray analysis. The data here used RNA sequencing (RNA-Seq) of Fhit-negative and Fhit-positive cells as proof of principle for the impact of Fhit on specific mRNAs, and to lay the foundation for a study using ribosome profiling to identify mRNAs whose translation is affected by FHIT loss.

Data description

RNA-Seq was performed on RNA from lines of Fhit-expressing and Fhit-deficient lung cancer cells. This identified changes in the leve

SUBMITTER: Kiss DL 

PROVIDER: S-EPMC5853088 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature