Relationship between mismatch repair immunophenotype and long-term survival in patients with resected periampullary adenocarcinoma.

ABSTRACT: BACKGROUND:Periampullary adenocarcinomas, including pancreatic cancer, are a heterogeneous group of tumors with poor prognosis, where classification into intestinal type (I-type) or pancreatobiliary type (PB-type) is a relevant prognostic factor. The clinical significance of deficient mismatch repair (dMMR) in periampullary adenocarcinoma is comparatively unexplored. Herein, we examined the associations of MMR immunophenotype with long-term survival in patients with resected periampullary adenocarcinoma, with particular reference to morphology and adjuvant treatment response. METHODS:MMR protein expression was assessed by immunohistochemistry on tissue microarrays with primary tumors from a retrospective cohort of 175 patients with periampullary adenocarcinoma treated with pancreaticoduode

SUBMITTER: Heby M 

PROVIDER: S-EPMC5853113 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature