Cerebrospinal fluid protein and glucose levels in neonates with a systemic inflammatory response without meningitis.

ABSTRACT:

Background

It has been estimated that paediatric meningitis without elevated CSF white cell count (pleocytosis) accounts for 0.5-12% of all cases of bacterial meningitis. CSF protein and glucose measurements are therefore essential in management but may be neglected in clinical practice. In order to improve recognition of bacterial meningitis in neonates and to enable adequate management and audit, we investigated whether a systemic inflammatory response in the absence of meningitis is associated with elevated CSF protein and reduced CSF glucose levels. A further aim was to determine whether abnormal levels of these parameters were associated with increased incidence of neurological damage.

Methods

As part of an audit into management of abnormal CSF findings in neonates, we

SUBMITTER: Noureldein M 

PROVIDER: S-EPMC5853144 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature