Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.

ABSTRACT:

Background

The mammalian genome is transcribed into large numbers of long noncoding RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, partly due to their low sequence conservation and lack of identified shared properties. Here we consider promoter conservation and positional conservation as indicators of functional commonality.

Results

We identify 665 conserved lncRNA promoters in mouse and human that are preserved in genomic position relative to orthologous coding genes. These positionally conserved lncRNA genes are primarily associated with developmental transcription factor loci with which they are coexpressed in a tissue-specific manner. Over half of positionally conserved RNAs in this set are linked to chromatin organization structures

SUBMITTER: Amaral PP 

PROVIDER: S-EPMC5853149 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature