Carbon load in airway macrophages as a biomarker of exposure to particulate air pollution; a longitudinal study of an international Panel.

ABSTRACT: BACKGROUND:Carbon load in airway macrophages (AM) has been proposed as an internal marker to assess long-term exposure to combustion-derived pollutant particles. However, it is not known how this biomarker is affected by changes in exposure. We studied the clearance kinetics of black carbon (BC) in AM, obtained by sputum induction, in a one-year panel study. METHODS:AM BC was measured 8 times with 6 weeks intervals in healthy young subjects: 15 long-term residents in Leuven, Belgium (BE, mean annual PM10 20-30 μg/m3) and 30 newcomers having arrived recently (< 3 weeks) in Leuven from highly polluted cities (mean annual PM10 > 50 μg/m3) in low and middle-income countries (LMIC, n = 15), or from low to moderately polluted cities in high-income countries (HIC, n = 15). The median and 90th per

SUBMITTER: Bai Y 

PROVIDER: S-EPMC5853150 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature