Impact of atopy on risk of glioma: a Mendelian randomisation study.

ABSTRACT:

Background

An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to assess the relationship with glioma risk using Mendelian randomisation (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations.

Methods

Two-sample MR was undertaken using genome-wide association study data. We used single nucleotide polymorphisms (SNPs) associated with atopic dermatitis, asthma and hay fever, IgE levels, and self-reported allergy as instrumental variables. We calculated MR estimates for the odds ratio (OR) for each risk factor with glioma using SNP-glioma estimates

SUBMITTER: Disney-Hogg L 

PROVIDER: S-EPMC5853158 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature