Detailed Transmission Network Analysis of a Large Opiate-Driven Outbreak of HIV Infection in the United States.

ABSTRACT: In January 2015, an outbreak of undiagnosed human immunodeficiency virus (HIV) infections among persons who inject drugs (PWID) was recognized in rural Indiana. By September 2016, 205 persons in this community of approximately 4400 had received a diagnosis of HIV infection. We report results of new approaches to analyzing epidemiologic and laboratory data to understand transmission during this outbreak. HIV genetic distances were calculated using the polymerase region. Networks were generated using data about reported high-risk contacts, viral genetic similarity, and their most parsimonious combinations. Sample collection dates and recency assay results were used to infer dates of infection. Epidemiologic and laboratory data each generated large and dense networks. Integration of these dat

SUBMITTER: Campbell EM 

PROVIDER: S-EPMC5853229 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature