The meiotic regulator JASON utilizes alternative translation initiation sites to produce differentially localized forms.

ABSTRACT: The JASON (JAS) protein plays an important role in maintaining an organelle band across the equator of male meiotic cells during the second division, with its loss leading to unreduced pollen in Arabidopsis. In roots cells, JAS localizes to the Golgi, tonoplast and plasma membrane. Here we explore the mechanism underlying the localization of JAS. Overall, our data show that leaky ribosom scanning and alternative translation initiation sites (TISs) likely leads to the formation of two forms of JAS: a long version with an N-terminal Golgi localization signal and a short version with a different N-terminal signal targeting the protein to the plasma membrane. The ratio of the long and short forms of JAS is developmentally regulated, with both being produced in roots but the short form being pr

SUBMITTER: Cabout S 

PROVIDER: S-EPMC5853252 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature