Impact of Pre-exposure History and Host Genetics on Antibody Avidity Following Norovirus Vaccination.

ABSTRACT:

Background

Development of high avidity, broadly neutralizing antibodies (Abs) is a priority after vaccination against rapidly evolving, widely disseminated viruses like human norovirus. After vaccination with a multivalent GI.1 and GII.4c norovirus virus-like particle (VLP) vaccine candidate adjuvanted with alum and monophosphoryl lipid A (MPL), blockade Ab titers peaked early, with no increase in titer following a second vaccine dose.

Methods

Blockade Ab relative avidity was evaluated by measuring the slope of blockade Ab neutralization curves.

Results

Blockade Ab avidity to the GI.1 vaccine component peaked at day 35 (7 days after dose 2). Avidities to heterotypic genogroup I VLPs were not sustained at day 35 after vaccination or GI.1 infection, as measured from arc

SUBMITTER: Lindesmith LC 

PROVIDER: S-EPMC5853323 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature