Group B Streptococcus and the Vaginal Microbiota.

ABSTRACT:

Background

Streptococcus agalactiae (group B Streptococcus [GBS]) is an important neonatal pathogen and emerging cause of disease in adults. The major risk factor for neonatal disease is maternal vaginal colonization. However, little is known about the relationship between GBS and vaginal microbiota.

Methods

Vaginal lavage samples from nonpregnant women were tested for GBS, and amplicon-based sequencing targeting the 16S ribosomal RNA V3-V4 region was performed.

Results

Four hundred twenty-eight of 432 samples met the high-quality read threshold. There was no relationship between GBS carriage and demographic characteristics, α-diversity, or overall vaginal microbiota community state type (CST). Within the non-Lactobacillus-dominant CST IV, GBS positive status was sign

SUBMITTER: Rosen GH 

PROVIDER: S-EPMC5853324 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature