Protection of the Human Gut Microbiome From Antibiotics.

ABSTRACT:

Background

Antibiotics are life-saving drugs but severely affect the gut microbiome with short-term consequences including diarrhea and selection of antibiotic-resistant bacteria. Long-term links to allergy and obesity are also suggested. We devised a product, DAV132, and previously showed its ability to deliver a powerful adsorbent, activated charcoal, in the late ileum of human volunteers.

Methods

We performed a randomized controlled trial in 28 human volunteers treated with a 5-day clinical regimen of the fluoroquinolone antibiotic moxifloxacin in 2 parallel groups, with or without DAV132 coadministration. Two control goups of 8 volunteers each receiving DAV132 alone, or a nonactive substitute, were added.

Results

The coadministration of DAV132 decreased free moxif

SUBMITTER: de Gunzburg J 

PROVIDER: S-EPMC5853327 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature