Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense Infection.

ABSTRACT:

Background

The progression of human African trypanosomiasis from the early hemolymphatic stage to the late meningoencephalitic stage is of critical diagnostic importance as it determines the choice of potentially toxic drug regimens. Current diagnostic criteria involving analysis of cerebrospinal fluid (CSF) for parasites and/or pleocytosis are sensitive, but recent evidence suggests that specificity may be poor.

Methods

We used an untargeted global metabolic profiling approach for the discovery of novel candidate stage-diagnostic markers in CSF from patients infected with Trypanosoma brucei rhodesiense, using 1H nuclear magnetic resonance (NMR) spectroscopy.

Results

Metabolic markers did not distinguish between early and late-stage cases but were associated with neur

SUBMITTER: Lamour SD 

PROVIDER: S-EPMC5853393 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature