Human Immunodeficiency Virus Type 1 Persistence Following Systemic Chemotherapy for Malignancy.

ABSTRACT:

Background

Systemic chemotherapies for various malignancies have been shown to significantly, yet transiently, decrease numbers of CD4+ T lymphocytes, a major reservoir for human immunodeficiency virus type 1 (HIV-1) infection. However, little is known about the impact of cytoreductive chemotherapy on HIV-1 reservoir dynamics, persistence, and immune responses.

Methods

We investigated the changes in peripheral CD4+ T-cell-associated HIV-1 DNA and RNA levels, lymphocyte activation, viral population structure, and virus-specific immune responses in a longitudinal cohort of 15 HIV-1-infected individuals receiving systemic chemotherapy or subsequent autologous stem cell transplantation for treatment of hematological malignancies and solid tumors.

Results

Despite a transie

SUBMITTER: Henrich TJ 

PROVIDER: S-EPMC5853412 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature