HIV Antibody Level as a Marker of HIV Persistence and Low-Level Viral Replication.

ABSTRACT:

Background

Human immunodeficiency virus (HIV) antibodies are generated and maintained by ongoing systemic expression of HIV antigen. We investigated whether HIV antibody responses as measured by high-throughput quantitative and qualitative assays could be used to indirectly measure persistent HIV replication in individuals receiving antiretroviral therapy (ART).

Methods

HIV antibody responses were measured over time in the presence or absence of suppressive ART and were compared to the HIV reservoir size and expression of antiviral restriction factors.

Results

Among untreated individuals, including both elite controllers (ie, persons with a viral load of ≤40 copies/mL) and noncontrollers, antibody parameters were stable over time and correlated with the individual vir

SUBMITTER: Keating SM 

PROVIDER: S-EPMC5853429 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature