Evidence for Viral Interference and Cross-reactive Protective Immunity Between Influenza B Virus Lineages.

ABSTRACT:

Background

Two influenza B virus lineages, B/Victoria and B/Yamagata, cocirculate in the human population. While the lineages are serologically distinct, cross-reactive responses to both lineages have been detected. Viral interference describes the situation whereby infection with one virus limits infection and replication of a second virus. We investigated the potential for viral interference between the influenza B virus lineages.

Methods

Ferrets were infected and then challenged 3, 10, or 28 days later with pairs of influenza B/Victoria and B/Yamagata viruses.

Results

Viral interference occurred at challenge intervals of 3 and 10 days and occasionally at 28 days. At the longer interval, shedding of challenge virus was reduced, and this correlated with cross-reactiv

SUBMITTER: Laurie KL 

PROVIDER: S-EPMC5853430 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature