The Role of Human Immunodeficiency Virus-Associated Vasculopathy in the Etiology of Stroke.

ABSTRACT:

Background

Human immunodeficiency virus (HIV) infection is a recognized risk factor for stroke among young populations, but the exact mechanisms are poorly understood. We studied the clinical, radiologic, and histologic features of HIV-related ischemic stroke to gain insight into the disease mechanisms.

Methods

We conducted a prospective, in-depth analysis of adult ischemic stroke patients presenting to Queen Elizabeth Central Hospital, Blantyre, Malawi, in 2011.

Results

We recruited 64 HIV-infected and 107 HIV-uninfected patients. Those with HIV were significantly younger (P < .001) and less likely to have established vascular risk factors. Patients with HIV were more likely to have large artery disease (21% vs 10%; P < .001). The commonest etiology was HIV-associate

SUBMITTER: Benjamin LA 

PROVIDER: S-EPMC5853476 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature