Dal81 Regulates Expression of Arginine Metabolism Genes in Candida parapsilosis.

ABSTRACT: Fungi can use a wide variety of nitrogen sources. In the absence of preferred sources such as ammonium, glutamate, and glutamine, secondary sources, including most other amino acids, are used. Expression of the nitrogen utilization pathways is very strongly controlled at the transcriptional level. Here, we investigated the regulation of nitrogen utilization in the pathogenic yeast Candida parapsilosis. We found that the functions of many regulators are conserved with respect to Saccharomyces cerevisiae and other fungi. For example, the core GATA activators GAT1 and GLN3 have a conserved role in nitrogen catabolite repression (NCR). There is one ortholog of GZF3 and DAL80, which represses expression of genes in preferred nitrogen sources. The regula

SUBMITTER: Turner SA 

PROVIDER: S-EPMC5853489 | biostudies-literature | 2018 Mar-Apr

REPOSITORIES: biostudies-literature