Thyroxine treatment in patients with symptoms of hypothyroidism but thyroid function tests within the reference range: randomised double blind placebo controlled crossover trial.

ABSTRACT:

Objectives

To determine whether thyroxine treatment is effective in patients with symptoms of hypothyroidism but with thyroid function tests within the reference range, and to investigate the effect of thyroxine treatment on psychological and physical wellbeing in healthy participants.

Design

Randomised double blind placebo controlled crossover trial.

Setting

Outpatient clinic in a general hospital.

Participants

25 patients with symptoms of hypothyroidism who had thyroid function tests within the reference range, and 19 controls.

Methods

PARTICIPANTS were given thyroxine 100 microgram or placebo to take once a day for 12 weeks. Washout period was six weeks. They were then given the other to take once a day for 12 weeks. All participants were assessed phy

SUBMITTER: Pollock MA 

PROVIDER: S-EPMC58535 | biostudies-literature | 2001 Oct

REPOSITORIES: biostudies-literature