Modeling of US Human Papillomavirus (HPV) Seroprevalence by Age and Sexual Behavior Indicates an Increasing Trend of HPV Infection Following the Sexual Revolution.

ABSTRACT:

Background

The United States has experienced an increase in the incidence of human papillomavirus (HPV)-related cancers that are not screen-detectable. It has been hypothesized, but not directly demonstrated, that this is due to increasing HPV prevalence in the unvaccinated population.

Methods

Female self-reported numbers of lifetime sex partners and HPV serology from the National Health and Nutrition Examination Survey (NHANES) were used to develop mathematical models of sexual partner acquisition and antibody dynamics. Modeled trends in sexual behaviors were compared to incidence data for cervical adenocarcinoma, oropharyngeal cancer, and anal cancer.

Results

The age-specific HPV seroprevalence data were best explained by a partner acquisition model that explicitly

SUBMITTER: Ryser MD 

PROVIDER: S-EPMC5853511 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature