Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.
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ABSTRACT:
SUBMITTER: Trapphoff T
PROVIDER: S-EPMC5853592 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
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Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.
Trapphoff T T Heiligentag M M Dankert D D Demond H H Deutsch D D Fröhlich T T Arnold G J GJ Grümmer R R Horsthemke B B Eichenlaub-Ritter U U
Human reproduction (Oxford, England) 20151117 1
<h4>Study question</h4>Is the postovulatory aging-dependent differential decrease of mRNAs and polyadenylation of mRNAs coded by maternal effect genes associated with altered abundance and distribution of maternal effect and RNA-binding proteins (MSY2)?<h4>Summary answer</h4>Postovulatory aging results in differential reduction in abundance of maternal effect proteins, loss of RNA-binding proteins from specific cytoplasmic domains and critical alterations of pericentromeric proteins without glob ...[more]
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