Maternal separation affects expression of stress response genes and increases vulnerability to ethanol consumption.

ABSTRACT:

Introduction

Maternal separation is an early life stress event associated with behavioral alterations and ethanol consumption. We aimed to expand the current understanding on the molecular mechanisms mediating the impact of postnatal stress on ethanol consumption.

Methods

In the first experiment (T1), some of the pups were separated from their mothers for 6 hr daily (Maternal Separation group - MS), whereas the other pups remained in the cage with their respective mothers (Control group - C). In the second experiment (T2), mice from both groups were subjected to the model of free-choice between water and sucrose solution or between water and ethanol solution. Maternal behavior was assessed at the end of T1. At the end of both T1 and T2, pups were subjected to the light/dark

SUBMITTER: de Almeida Magalhaes T 

PROVIDER: S-EPMC5853632 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature