Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus.

ABSTRACT:

Introduction

Type 2 diabetes mellitus is associated with global and hippocampal atrophy and cognitive deficits, and some studies suggest that the right hippocampus may display greater vulnerability than the left.

Methods

Hippocampal volumes, the hippocampal asymmetry index, and cognitive functioning were assessed in 120 nondemented adults with long duration type 2 diabetes.

Results

The majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). After adjustment for age, sex, and IQ, right (but not left) hippocampal volumes were negatively associated with memory, executive function, and semantic fluency. These associations were stronger with the hippocampal asymmetry index and r

SUBMITTER: Milne NT 

PROVIDER: S-EPMC5853633 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature