Rotavirus Infection and Disease in a Multisite Birth Cohort: Results From the MAL-ED Study.

ABSTRACT:

Background

In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs.

Methods

Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays.

Results

A total of 1737 children contributed 22646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consist

SUBMITTER: Mohan VR 

PROVIDER: S-EPMC5853665 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature