Race/Ethnicity and the Pharmacogenetics of Reported Suicidality With Efavirenz Among Clinical Trials Participants.

ABSTRACT:

Background

We examined associations between suicidality and genotypes that predict plasma efavirenz exposure among AIDS Clinical Trials Group study participants in the United States.

Methods

Four clinical trials randomly assigned treatment-naive participants to efavirenz-containing regimens; suicidality was defined as reported suicidal ideation or attempted or completed suicide. Genotypes that predict plasma efavirenz exposure were defined by CYP2B6 and CYP2A6 polymorphisms. Associations were evaluated with weighted Cox proportional hazards models stratified by race/ethnicity. Additional analyses adjusted for genetic ancestry and selected covariates.

Results

Among 1833 participants, suicidality was documented in 41 in exposed analyses, and 34 in on-treatment analyses.

SUBMITTER: Mollan KR 

PROVIDER: S-EPMC5853681 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature