Alternative Sample Types for HIV-1 Antiretroviral Drug Resistance Testing.

ABSTRACT: Monitoring human immunodeficiency virus type 1 (HIV-1) drug resistance is critical for assessing ART effectiveness and treatment outcomes for HIV-1-infected individuals, including children, worldwide. Traditionally, testing for HIV-1 drug resistance has primarily been performed on plasma samples, and with commercially available, clinically validated assays that are costly and difficult to access. While plasma is the preferred sample for HIV-1 drug resistance genotyping, plasma analysis requires sophisticated laboratory equipment, personnel, space, and stringent storage conditions for maintenance of sample integrity and transport. With the limitations in feasibility and affordability of providing these ideal conditions for plasma genotyping in resource-constrained settings, the field has ga

SUBMITTER: Singh D 

PROVIDER: S-EPMC5853792 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature