Ontology highlight
ABSTRACT:
SUBMITTER: Gendrin C
PROVIDER: S-EPMC5853813 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20180301 6
Group B streptococci (GBS) are Gram-positive bacteria that are a leading cause of neonatal infections. Most invasive isolates are β-hemolytic, and hemolytic activity is critical for GBS virulence. Although nonhemolytic GBS strains are occasionally isolated, they are often thought to be virulence attenuated. In this study, we show that a nonhemolytic GBS strain (GB37) isolated from a septic neonate exhibits hypervirulence. Substitution of tryptophan to leucine (W297L) in the sensor histidine kina ...[more]