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HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D.

ABSTRACT: Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher HIV RNA (P trend = .05), and without highly active antiretroviral therapy (P = .03). These associations were not observed for SFTPD. Serum levels of pro-SFTPB are elevated among PWH and are associated with immunosuppression and uncontrolled viremia.

SUBMITTER: Shiels MS

PROVIDER: S-EPMC5853828 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature

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HIV Infection and Circulating Levels of Prosurfactant Protein B and Surfactant Protein D.

Shiels Meredith S MS Kirk Gregory D GD Drummond M Bradley MB Dhillon Dilsher D Hanash Samir M SM Taguchi Ayumu A Engels Eric A EA

The Journal of infectious diseases 20180101 3

Prosurfactant protein B (pro-SFTPB) and surfactant protein D (SFTPD) are markers of lung inflammation and damage. We estimated geometric mean pro-SFTPB and SFTPD levels in 500 human immunodeficiency virus (HIV)-infected and 300 HIV-uninfected injection drug users, adjusting for smoking and other covariates. Pro-SFTPB levels were significantly higher among people with HIV (PWH) (adjusted geometric mean, 21.4 vs 18.1 ng/mL; P = .03), and were higher with lower CD4 counts (P trend = .001), higher H ...[more]

PMID: 29272472

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