Evaluating the Impact of Functional Genetic Variation on HIV-1 Control.

ABSTRACT:

Background

Previous genetic association studies of human immunodeficiency virus-1 (HIV-1) progression have focused on common human genetic variation ascertained through genome-wide genotyping.

Methods

We sought to systematically assess the full spectrum of functional variation in protein coding gene regions on HIV-1 progression through exome sequencing of 1327 individuals. Genetic variants were tested individually and in aggregate across genes and gene sets for an influence on HIV-1 viral load.

Results

Multiple single variants within the major histocompatibility complex (MHC) region were observed to be strongly associated with HIV-1 outcome, consistent with the known impact of classical HLA alleles. However, no single variant or gene located outside of the MHC region

SUBMITTER: McLaren PJ 

PROVIDER: S-EPMC5853944 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature