A replication study and meta-analysis of mitochondrial DNA variants in the radiographic progression of knee osteoarthritis.

ABSTRACT:

Objective

To conduct a replication study and meta-analysis involving the study of mtDNA variants in the radiographic progression of OA in different cohorts worldwide, including Cohort Hip and Cohort Knee (CHECK), the OA Initiative and a cohort from Spain.

Methods

The influence of the haplogroups in the rate of radiographic progression at 96 months in 431 subjects from CHECK was assessed in terms of Kellgren and Lawrence (KL) grade. Progression was defined as a change from KL ⩾ 1 at baseline to any higher grade during the follow-up. Extended Cox proportional hazard models were used to analyse the influence of mtDNA variants in the rate of radiographic knee OA progression. A subsequent meta-analysis of 1603 subjects following the Preferred Reporting Items for Systematic Review

SUBMITTER: Fernandez-Moreno M 

PROVIDER: S-EPMC5854036 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature