Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis.

ABSTRACT:

Objective

To identify novel biomarker(s) for predicting advanced knee OA.

Methods

Study participants were derived from the Newfoundland Osteoarthritis Study and the Tasmania Older Adult Cohort Study. All knee OA cases were patients who underwent total knee replacement (TKR) due to primary OA. Metabolic profiling was performed on fasting plasma. Four thousand and eighteen plasma metabolite ratios that were highly correlated with that in SF in our previous study were generated as surrogates for joint metabolism.

Results

The discovery cohort included 64 TKR cases and 45 controls and the replication cohorts included a cross-sectional cohort of 72 TKR cases and 76 controls and a longitudinal cohort of 158 subjects, of whom 36 underwent TKR during the 10-year follow-up peri

SUBMITTER: Zhang W 

PROVIDER: S-EPMC5854095 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature