Fitness Trade-Offs Lead to Suppressor Tolerance in Yeast.

ABSTRACT: Genetic variation among individuals within a population provides the raw material for phenotypic diversity upon which natural selection operates. Some given variants can act on multiple standing genomic variations simultaneously and release previously inaccessible phenotypes, leading to increased adaptive potential upon challenging environments. Previously, we identified such a variant related to a tRNA nonsense suppressor in yeast. When introduced into other genetic backgrounds, the suppressor led to an increased population phenotypic variance on various culture conditions, conferring background and environment specific selective advantages. Nonetheless, most isolates are intolerant to the suppressor on rich media due to a severe fitness cost. Here, we found that the tolerance to suppress

SUBMITTER: Hou J 

PROVIDER: S-EPMC5854122 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature