Joint effects of OSA and self-reported sleepiness on incident CHD and stroke.

ABSTRACT: BACKGROUND:Although excessive daytime sleepiness (EDS) is a common symptom of obstructive sleep apnea (OSA), and both EDS and OSA have separately been associated with increased risk of cardiovascular disease (CVD), their joint association with CVD risk is unknown. METHODS:Among 3874 Sleep Heart Health Study (SHHS) participants without prevalent CVD, moderate to severe OSA was defined by an apnea hypopnea index (AHI) ≥ 15 on an in-home polysomnography. EDS was defined as an Epworth Sleepiness Scale score ≥11. Incident CVD events included total CVD events (coronary heart disease (CHD) and stroke), as well as CHD and stroke separately. Cox proportional hazards models adjusted for age, sex, alcohol, smoking, and body mass index. RESULTS:Compared to those with AHI <15, the hazard ratios (95% CI

SUBMITTER: Ogilvie RP 

PROVIDER: S-EPMC5854212 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature