Type 2 diabetes is associated with loss of HDL endothelium protective functions.

ABSTRACT:

Aims/hypothesis

One of the hallmarks of diabetes is impaired endothelial function. Previous studies showed that HDL can exert protective effects on endothelium stimulating NO production and protecting from inflammation and suggested that HDL in obese people with diabetes and dyslipidemia may have lower endothelial protective function. We aimed to investigate whether type 2 diabetes impairs HDL endothelium protective functions in people with otherwise normal lipid profile.

Methods

In a case-control study (n = 41 per group) nested in the Cooper Center Longitudinal Study we tested the ability of HDL to protect endothelium by stimulating endothelial nitric oxide synthase activity and suppressing NFκB-mediated inflammatory response in endothelial cells. In parallel we measured HD

SUBMITTER: Vaisar T 

PROVIDER: S-EPMC5854245 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature