Chronic hepatitis B infection and non-hepatocellular cancers: A hospital registry-based, case-control study.

ABSTRACT:

Background

Prior epidemiological evidences suggest that hepatitis B virus (HBV) infection is linked to cancers other than hepatocellular carcinoma. This prospective hospital registry-based case-control study aimed to investigate the sero-epidemiological association between chronic HBV infection and various types of cancer.

Methods

95,034 patients with first-diagnosed non-hepatocellular malignancy in a tertiary hospital between 2007 and 2014; and 118,891 non-cancer individuals as controls from a health promotion center were included. Cases and controls were compared for HBV surface antigen (HBsAg) positivity by conditional regression with adjustment for age, hypertension, diabetes, body mass index, alcohol consumption, smoking status and cholesterol level in both genders.

SUBMITTER: An J 

PROVIDER: S-EPMC5854295 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature