Opening of the human epithelial calcium channel TRPV6.

ABSTRACT: Calcium-selective transient receptor potential vanilloid subfamily member 6 (TRPV6) channels play a critical role in calcium uptake in epithelial tissues. Altered TRPV6 expression is associated with a variety of human diseases, including cancers. TRPV6 channels are constitutively active and their open probability depends on the lipidic composition of the membrane in which they reside; it increases substantially in the presence of phosphatidylinositol 4,5-bisphosphate. Crystal structures of detergent-solubilized rat TRPV6 in the closed state have previously been solved. Corroborating electrophysiological results, these structures demonstrated that the Ca²⁺ selectivity of TRPV6 arises from a ring of aspartate side chains in the selectivity filter that binds Ca²⁺ tightly

SUBMITTER: McGoldrick LL 

PROVIDER: S-EPMC5854407 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature