CD39 and immune regulation in a chronic helminth infection: The puzzling case of Mansonella ozzardi.

ABSTRACT:

Background

Chronic helminth infections typically induce an immunoregulatory environment, with markedly reduced immune responses to both parasite-specific and unrelated bystander antigens. Here we tested whether these changes are also observed in human infections with Mansonella ozzardi, a neglected filarial nematode widely distributed across Latin America.

Methods

CD4+ T cell populations from microfilaremic (Fil+) and uninfected (Fil-) inhabitants in M. ozzardi-endemic riverine communities in Brazil were characterized by flow cytometry analysis. Plasma concentrations of a wide range of cytokines and chemokines were measured. We examined whether M. ozzardi infection is associated with suppressed in vitro lymphoproliferative and inflammatory cytokine responses upon stimulation

SUBMITTER: Lima NF 

PROVIDER: S-EPMC5854421 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature