A computational model for how cells choose temporal or spatial sensing during chemotaxis.

ABSTRACT: Cell size is thought to play an important role in choosing between temporal and spatial sensing in chemotaxis. Large cells are thought to use spatial sensing due to large chemical difference at its ends whereas small cells are incapable of spatial sensing due to rapid homogenization of proteins within the cell. However, small cells have been found to polarize and large cells like sperm cells undergo temporal sensing. Thus, it remains an open question what exactly governs spatial versus temporal sensing. Here, we identify the factors that determines sensing choices through mathematical modeling of chemotactic circuits. Comprehensive computational search of three-node signaling circuits has identified the negative integral feedback (NFB) and incoherent feedforward (IFF) circuits as capable o

SUBMITTER: Tan RZ 

PROVIDER: S-EPMC5854446 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature