Stereocontrolled Synthesis of Kalihinol C.

ABSTRACT: We report a concise chemical synthesis of kalihinol C via a possible biosynthetic intermediate, "protokalihinol", which was targeted as a scaffold en route to antiplasmodial analogs. High stereocontrol of the kalihinol framework relies on a heterodendralene cascade to establish the target stereotetrad. Common problems of regio- and chemoselectivity encountered in the kalihinol class are explained and solved.

SUBMITTER: Reiher CA 

PROVIDER: S-EPMC5854479 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature