Interleukin-6 is independently associated with right ventricular function in pulmonary arterial hypertension.

ABSTRACT:

Background

An elevated serum level of interleukin-6 (IL-6) in pulmonary arterial hypertension (PAH) patients results in a greater symptom burden and increased mortality; however, the mechanisms underlying these observations remain unclear. Because both pre-clinical and clinical data associate elevated IL-6 levels with impaired cardiac function, we hypothesized that the adverse effects of IL-6 in PAH result, in part, from right ventricular (RV) dysfunction.

Methods

We analyzed the relationship between IL-6 and RV function in 40 patients with PAH identified in our institutional PAH registry. Serum IL-6 levels was quantified by enzyme-linked immunoassay.

Results

PAH patients had higher IL-6 levels than age- and gender-matched controls. Circulating IL-6 levels correlated

SUBMITTER: Prins KW 

PROVIDER: S-EPMC5854490 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature