Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens.

ABSTRACT: Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, with current treatment remaining palliative. Immunotherapies harness the body's own immune system to target cancers and could overcome the limitations of conventional treatments. One active immunotherapy strategy uses dendritic cell (DC)-based vaccination to initiate T-cell-mediated antitumor immunity. It has been proposed that cancer stem-like cells (CSCs) may play a key role in cancer initiation, progression, and resistance to current treatments. However, whether using human CSC antigens may improve the antitumor effect of DC vaccination against human cancer is unclear. In this study, we explored the suitability of CSCs as sources of antigens for DC vaccination again human GBM, with the aim of achieving CSC-targeti

SUBMITTER: Xu Q 

PROVIDER: S-EPMC5854496 | biostudies-literature | 2009 Aug

REPOSITORIES: biostudies-literature