HIV-positive women have higher risk of human papilloma virus infection, precancerous lesions, and cervical cancer.

ABSTRACT: OBJECTIVE:HIV-positive women have higher human papillomavirus (HPV) prevalence and cervical cancer incidence than HIV-negative women, partly because of HIV's modifying effect on HPV pathogenesis. We synthesized the literature on the impact of HIV on HPV natural history. DESIGN:Systematic review and meta-analysis. METHODS:We searched the literature for studies evaluating HPV acquisition and persistence or precancer progression by HIV status. Data on HPV natural history by HIV status, CD4 cell counts, viral load, and antiretroviral therapy (ART) were summarized using fixed effect models. RESULTS:Overall, 38 of 1845 abstracts identified met inclusion criteria. HIV-positive women had higher HPV acquisition [relative risk (RRpooled) 2.64, 95% confidence interval (CI) 2.04-3.42] and lower HPV cl

SUBMITTER: Liu G 

PROVIDER: S-EPMC5854529 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature