Orchestrated control of filaggrin-actin scaffolds underpins cornification.

ABSTRACT: Epidermal stratification critically depends on keratinocyte differentiation and programmed death by cornification, leading to formation of a protective skin barrier. Cornification is dynamically controlled by the protein filaggrin, rapidly released from keratohyalin granules (KHGs). However, the mechanisms of cornification largely remain elusive, partly due to limitations of the observation techniques employed to study filaggrin organization in keratinocytes. Moreover, while the abundance of keratins within KHGs has been well described, it is not clear whether actin also contributes to their formation or fate. We employed advanced (super-resolution) microscopy to examine filaggrin organization and dynamics in skin and human keratinocytes during differentiation. We found that filaggrin orga

SUBMITTER: Gutowska-Owsiak D 

PROVIDER: S-EPMC5854575 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature