Rare variants in drug target genes contributing to complex diseases, phenome-wide.

ABSTRACT: The DrugBank database consists of ~800 genes that are well characterized drug targets. This list of genes is a useful resource for association testing. For example, loss of function (LOF) genetic variation has the potential to mimic the effect of drugs, and high impact variation in these genes can impact downstream traits. Identifying novel associations between genetic variation in these genes and a range of diseases can also uncover new uses for the drugs that target these genes. Phenome Wide Association Studies (PheWAS) have been successful in identifying genetic associations across hundreds of thousands of diseases. We have conducted a novel gene based PheWAS to test the effect of rare variants in DrugBank genes, evaluating associations between these genes and more than 500 quantitative

SUBMITTER: Verma SS 

PROVIDER: S-EPMC5854600 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature