Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection.

ABSTRACT: Zika virus (ZIKV) disease has become a global health emergency with devastating effects on public health. Recent evidences implicate the virus as an emergent neuropathological agent promoting serious pathologies of the human nervous system, that include destructive and malformation consequences such as development of ocular and fetal brain lesions, microcephaly in neonates, and Guillain-Barré syndrome (GBS) in adults. These neurological disorders of both central and peripheral nervous systems are thought to be associated to the neurotropic properties of the virus that has ability to infect neural stem cells as well as peripheral neurons, a hallmark of its pathogenicity. The presence of autoantibodies against gangliosides plays a pivotal role in the etiogenesis of GBS and a variety of neuro

SUBMITTER: Nico D 

PROVIDER: S-EPMC5854646 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature