PARP inhibitors in platinum-sensitive high-grade serous ovarian cancer.

ABSTRACT: PURPOSE:Poly(ADP-ribose) polymerase inhibitors (PARPi) have changed the management of high-grade serous ovarian cancer (HGSOC). The rationale for the development of PARPi was based on the concept of synthetic lethality, in which a cell can survive a deficiency of one gene/gene product, but may die if there is a deficiency in a combination of genes/gene products. In women with BRCA1/2 deficiency within their ovarian cancer tissue, inhibition of PARP imposes an intolerable burden of DNA damage repair deficiency and may induce cell death. METHODS:Clinical trials have evaluated PARPi as single-agent therapeutics and as maintenance treatment following platinum-based chemotherapy for HGSOC. Clinical data suggest the most impressive anti-tumour activity occurs in women with platinum-sensitive ova

SUBMITTER: Morgan RD 

PROVIDER: S-EPMC5854713 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature