Synthesis, molecular docking, ctDNA interaction, DFT calculation and evaluation of antiproliferative and anti-Toxoplasma gondii activities of 2,4-diaminotriazine-thiazole derivatives.

ABSTRACT: Synthesis, characterization, and investigation of antiproliferative activities against human cancer cell lines (MV4-11, MCF-7, and A549) and Toxoplasma gondii parasite of twelve novel 2,4-diaminotriazine-thiazoles are presented. The toxicity of the compounds was studied at three different cell types, normal mouse fibroblast (Balb/3T3), mouse fibroblast (L929), and human VERO cells. The structures of novel compounds were determined using ¹H and ¹³C NMR, FAB(+)-MS, and elemental analyses. Among the derivatives, 4a-k showed very high activity against MV4-11 cell line with IC₅₀ values between 1.13 and 3.21 µg/ml. Additionally, the cytotoxic activity of compounds 4a-k against normal mouse fibroblast Balb/3T3 cells is about 20-1

SUBMITTER: Laczkowski KZ 

PROVIDER: S-EPMC5854716 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature