Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.

ABSTRACT: Chronic kidney disease and hyperuricemia are serious global health problems. Recent genome-wide association studies have identified various genetic variants related to these disorders. However, most studies have been conducted in a cross-sectional manner. To identify novel susceptibility loci for chronic kidney disease or hyperuricemia, we performed longitudinal exome-wide association studies (EWASs), using ~ 244,000 genetic variants and clinical data of Japanese individuals who had undergone annual health checkups for several years. After establishing quality controls, the association of renal function-related traits in 5648 subjects (excluding patients with dialysis and population outliers) with 24,579 single nucleotide variants (SNVs) for three genetic models (P < 3.39 × 10^- 7

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC5854719 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature